30 July 2012
Last updated at 17:03 GMT
The UK government said his decision represented the "revulsion and despair" of Syrians.
The announcement came after the UN said some 200,000 people have fled intense fighting in Syria's second city Aleppo.
An FCO spokesman said: "Mr al-Ayoubi has told us that he is no longer willing to represent a regime that has committed such violent and oppressive acts against its own people, and is therefore unable to continue in his position.
"Mr al-Ayoubi was the most senior Syrian diplomat serving in London.
"His departure is another blow to the Assad regime. It illustrates the revulsion and despair the regime's actions are provoking amongst Syrians from all walks of life, inside the country and abroad.
"We urge others around Bashar al-Assad to follow Mr al-Ayoubi's example, to disassociate themselves from the crimes being committed against the Syrian people and to support a peaceful and free future for Syria."
Series of defections The Foreign Office said Mr al-Ayoubi is staying in a safe location in the UK but has not yet revealed if he will support the Syrian rebels.
The Syrian government has been hit by a series of defections, including three high-ranking diplomats and a number of military commanders.
Mr Assad withdrew his ambassador in March and Mr al-Ayoubi's departure leaves five staff at the Syrian embassy after his predecessor and two others were expelled in May.
Foreign Affairs Select Committee chairman Richard Ottaway welcomed the "defection" and said it was evidence of "the continuing collapse of the Assad regime".
Syria diplomat quits UK post in 'protest' at Assad regime
Syria's most senior UK diplomat has quit his post, the Foreign Office has said.
Charge d'Affaires Khaled al-Ayoubi told British authorities
he was resigning over his government's "violent and oppressive acts".The UK government said his decision represented the "revulsion and despair" of Syrians.
The announcement came after the UN said some 200,000 people have fled intense fighting in Syria's second city Aleppo.
An FCO spokesman said: "Mr al-Ayoubi has told us that he is no longer willing to represent a regime that has committed such violent and oppressive acts against its own people, and is therefore unable to continue in his position.
"Mr al-Ayoubi was the most senior Syrian diplomat serving in London.
"His departure is another blow to the Assad regime. It illustrates the revulsion and despair the regime's actions are provoking amongst Syrians from all walks of life, inside the country and abroad.
"We urge others around Bashar al-Assad to follow Mr al-Ayoubi's example, to disassociate themselves from the crimes being committed against the Syrian people and to support a peaceful and free future for Syria."
Series of defections The Foreign Office said Mr al-Ayoubi is staying in a safe location in the UK but has not yet revealed if he will support the Syrian rebels.
The Syrian government has been hit by a series of defections, including three high-ranking diplomats and a number of military commanders.
Mr Assad withdrew his ambassador in March and Mr al-Ayoubi's departure leaves five staff at the Syrian embassy after his predecessor and two others were expelled in May.
Foreign Affairs Select Committee chairman Richard Ottaway welcomed the "defection" and said it was evidence of "the continuing collapse of the Assad regime".
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